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KMID : 0358819840110040427
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1984 Volume.11 No. 4 p.427 ~ p.435
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THE EFFECT OF PROSTAGLANDINS ON SURVIVAL OF SKIN FLAPS IN RATS
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Chng Won-Jin
Lee Sang-Heon
Shin Keuk-Shun
Lee Young-Ho
You Jae-Duk
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Abstract
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As to survive, the flap must maintain the blood supply to its own.
In recent years, many attempts have been made clinically and experimentally to improve the blood supply in ischemic random pattern flaps. It is reasonable to speculate that the mechanical stimuli during the construction of skin flap may result in release of certain kinds of prostaglandins which cause vasoconstruction, thrombus formation and even vasodilatation. It is probably one of the major detrimental factors responsible for the failure of the constructed skin flap.
This study was designed to clarify the certain facts of prostaglandin synthesis following the flap construction and reconfirm the actions of various prostaglandins in regard with the flap survival.
A total of 40 male white rats was grouped into 4; the control, group Ⅰ treated with flurbiprofen as prostaglandin inhibitor, group Ⅱ treated with flurbiprofen and prostaglandin E₂ as vasodilator, and group Ⅲ treated with flurbiprofen and prostaglandin F₂α as vasodilator. Each animal had a flap on the back measuring 2×8cm and was observed for the flap survival daily for one week and the following results were summerized;
1. Group Ⅰtreated with flurbiprofen which inhibit prostaglandin and thromboxane synthesis showed significant increase of the area of flap survival compared with the control.
2. The flap survival was best improved in the group Ⅱtreated with flurbiprofen and vasodilating prostaglandin(PGE₂) and worse in the group Ⅲ treated with vasoconstricting prostaglandin(PGF₂α).
3. It is suggested that prostaglandins act on distal part of the flap because no vascular changes were noted at proximal part of the flaps on histological study.
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KEYWORD
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